With all of that said, you probably can make some tweaks to improve system performance, including creating mutual exclusions between Malwarebytes and Windows Defender. I've used all the top AVs and tons of other anti-malware applications and utilities, but Malwarebytes, especially the latest version Malwarebytes 3 with all of the new protection layers it has added has proven itself to be one of the most robust and effective solutions available, at least in my opinion.
I've personally been dealing with viruses and malware for around 15 years, and in all that time through extensive personal use and testing I've never come across a single solution that I absolutely will not do without besides Malwarebytes. You could of course use Defender on its own and disable Malwarebytes, but I honestly wouldn't advise that knowing how much the various layers of defense in Malwarebytes improve the security of a system and I truly believe you'd be better off keeping Malwarebytes either way.
It's up to you whether you run both, and the two together are definitely a good combination (Malwarebytes is deliberately engineered not to interfere with other security software, especially general antivirus applications like Windows Defender) that said, if you would prefer to use only one then you can disable Windows Defender and use Malwarebytes alone if you wish.
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